Volume 4, Issue 3, May 2016, Page: 214-218
Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria
Egbe Kingsley, Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria
Ike Anthony C., Department of Microbiology, University of Nigeria, Nsukka, Enugu State, Nigeria
Aleruchi Chuku, Department of Microbiology, Federal University Lafia, Nasarawa State, Nigeria
Received: Apr. 18, 2016;       Accepted: Apr. 25, 2016;       Published: May 13, 2016
DOI: 10.11648/j.sjph.20160403.18      View  3248      Downloads  84
Abstract
Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a clinical and public health challenge in Nigeria. This study was carried out to determine the prevalence of M. tuberculosis and rifampicin resistance in patients from five selected health facilities in Nasarawa State, Nigeria. The HIV serostatus and the CD4+ count of seropositive individuals were also determined. Using a combination of Zhiel Neelsen staining and WHO approved GeneXpert MTB/Rif device for M. tuberculosis and rifampicin resistance, the presence of M. tuberculosis in sputum samples was detected and confirmed. A total of 346 samples were analysed, out of which M. tuberculosis was detected in 91 (26.3%) samples and rifampicin resistance in 6 (6.6%) of the positive samples. HIV prevalence was found to be 46.8%, HIV and TB co-infection 39.6%, while 83.3% of the rifampicin resistance was from HIV positive cases. Tuberculosis was found to be decreasing with increase in CD4 count. Statistically, there was a significant relationship (P < 0.05), between level of education, HIV, CD4 count and TB occurrence. However, no significant relationship (P > 0.05) between gender, occupation and age with TB was observed. Our results show that tuberculosis still remains endemic in Nasarawa state with a high prevalence of HIV and that the confluence of HIV and tuberculosis increased the rate of rifampicin resistance. Provision of Tuberculosis diagnostics with the capacity to detect TB drug resistance beyond rifampicin is highly recommended.
Keywords
Tuberculosis, Rifampicin Resistance, GeneXpert MTB/Rif, Human Immunodeficiency Virus, CD4 Count
To cite this article
Egbe Kingsley, Ike Anthony C., Aleruchi Chuku, Prevalence of Tuberculosis and Rifampicin Resistance Among Patients Seeking Medical Care in Nasarawa State, North Central Nigeria, Science Journal of Public Health. Vol. 4, No. 3, 2016, pp. 214-218. doi: 10.11648/j.sjph.20160403.18
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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