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The Efficacy and Safety of Integrated Chinese Plus Western Medicine Compared with Western Medicine Alone in the Treatment for Purpuric Nephritis: A Meta-Aalysis
Changchun Shi,
Meng Peng,
Yingying Du,
Wenxing Li,
Yonghan Hu,
Tingting Wu
Issue:
Volume 8, Issue 2, March 2020
Pages:
19-35
Received:
9 January 2020
Accepted:
27 January 2020
Published:
10 March 2020
Abstract: Objective: This research is aimed to systematically evaluate the efficacy and safety of Chinese plus Western Medicine treatment for Childhood purpuric nephritis by Meta-analysis, in order to improve the cure rate and reduce adverse reactions of this disease, then provide guidance for clinical medication. Methods: There are six major databases including CNKI, Pubmed, Embase, World Wide Database, Web of science and Science Direct retrieved through the Internet, and the randomized-controlled trials of the combined therapy for Childhood purpuric nephritis published both in Chinese and English from the 1999 to October 2019 were collected. Meta-analysis by R software 3.5.0 was adopted to analyze the effective index and adverse effect. Results: In total 92 papers of randomized-controlled clinical studies were enrolled. HSPN children treated with combined therapy demonstrated a significant increase in total effective rate (RR=1.19; 95%CI (1.16–1.21), P<0.001) when compared with Western medicine alone. Our study also found that Chinese plus Western medicine had an advantage on decreasing 24-hour urine protein (WMD=-0.47; 95%CI (-0.53,-0.41); p<0.001) and urine erythrocyte count (WMD=-8.88; 95%CI (-9.80,-7.96); p<0.001) when compared with Western medicine. Children seemed to benefit more from combined treatment in the adverse effect (RR=0.64; 95%CI (0.46, 0.87); p<0.01). Conclusions: Integrated Chinese plus Western medicine treatment was effective for Childhood purpuric nephritis, which may be a superior alternative for HSPN. Nevertheless, long-term, high-quality and multicenter RCTs are required to make the results more convincing.
Abstract: Objective: This research is aimed to systematically evaluate the efficacy and safety of Chinese plus Western Medicine treatment for Childhood purpuric nephritis by Meta-analysis, in order to improve the cure rate and reduce adverse reactions of this disease, then provide guidance for clinical medication. Methods: There are six major databases inclu...
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Treatment Outcome of Severe Acute Malnutrition Among Children (6-59 Months) in Outpatient Therapeutic Feeding Program in Gursum District, Somali Region, Ethiopia
Abdulahi Bedel Budul,
Alinoor Mohamed Farah,
Tahir Yusuf Nour
Issue:
Volume 8, Issue 2, March 2020
Pages:
36-42
Received:
5 February 2020
Accepted:
27 February 2020
Published:
17 March 2020
Abstract: Severe Acute Malnutrition (SAM) is one of public health problems in developing countries which mainly affect under five children. Ethiopia is one of the countries with uppermost under-five child mortality rate, in which malnutrition contributes to 57% of all children’s death. This study provides an insight based on management of SAM and help to improve the management of severe acute malnutrition in outpatient therapeutic program (OTP). This study aimed to assess treatment outcomes of severe acute malnutrition and associated factors among children treated at outpatient program in Gursum woreda, Eastern Ethiopia. Facility-based retrospective cross-sectional study was conducted in outpatient program records of 350 children, treated at twelve health facilities obtained from January 1, 2016 to December 31, 2018. Proportional allocation was conducted to get sample size for each selected health facility and outpatient program sites within woreda. Individual cards of children were selected by systematic random sampling. Data were entered using Epi data software version 3.1 and exported to SPSS version 22 for cleaning and further analysis. Crude and Adjusted odd ratio along with the 95% confidence interval were estimated by using bivariate and multivariate logistic regressions to identify factors associated with treatment outcome. Level of significance was declared at P-value less or equal to 0.25 and 0.05 respectively. The recovery rate of sever acute malnutrition was 81.7%. Death rate, defaulter rate, weight gain, and length of stay were 0%, 12.6%, 3.8g/kg/day and 6.7 weeks respectively. The odd of recovery was 2.5 times higher for children with kwashiorkor than children with marasmus (AOR: 2.877, 95% CI: 1.141, 7.255, P=0.025), and those children with self-referral were 57.4% more likely to recover than their counterpart. The average weight gain and length of stay were not in acceptable range of international SPHERE Standard. Also Type of malnutrition and self-referral were factors identified as significant associated with treatment outcome of severe acute malnutrition. Capacity building of OTP service providers, regular monitoring of service provision based on the severe acute management protocol and awareness creation of community were recommended.
Abstract: Severe Acute Malnutrition (SAM) is one of public health problems in developing countries which mainly affect under five children. Ethiopia is one of the countries with uppermost under-five child mortality rate, in which malnutrition contributes to 57% of all children’s death. This study provides an insight based on management of SAM and help to imp...
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Prevalence of Exclusive Breastfeeding Practice and Its Associated Factors Among Mothers with Children Aged 6 - 12 Months in Hargeisa City, Somaliland
Ahmed Ismail Mohamed,
Yonatan Tegene,
Kiruja Jonah
Issue:
Volume 8, Issue 2, March 2020
Pages:
43-49
Received:
7 February 2020
Accepted:
16 March 2020
Published:
14 April 2020
Abstract: Breastfeeding has many health benefits for both mother and infant. Breast milk contains all the nutrients an infant need in the first 6 months of life. Exclusive breastfeeding is the most widely known and effective intervention for preventing early-childhood deaths. Optimum breastfeeding practices can prevent 1.4 million deaths worldwide among children under five every year. The aim of this study was to assess the prevalence of exclusive breastfeeding and associated factors among mothers who have an infant six months up to one year old in Hargeisa, Somaliland. A community based cross-sectional study was conducted from November to December, 2019. A cluster along with simple random sampling technique was used to select sample population. A total of 357 mothers with children aged six months to one year old were included in this study. Data were collected using questionnaires administered at interview. Both bivariate and multivariate logistic regression analyses were carried out to identify factors associated with exclusive breastfeeding. The prevalence of exclusive breastfeeding was 68%. Those mothers who were heard information on EBF [AOR=14.243 CI (4.630, 43.816)], attend ANC service [AOR=25.412 (3.506, 184.179)], received breastfeeding counseling during antenatal care (ANC) [AOR=6.037 (2.878, 12.666)], aware that breastfeeding is enough the child up to six months [AOR=3.411 (1.536, 7.577)], and had fed colostrum [AOR=4.663 CI (2.107, 10.321)] were more likely to practice EBF than their counterparts. The proportion of exclusive breastfeeding in the city was below WHO Infant and Young Child Feeding recommendations. The practice of exclusive breastfeeding in mothers of under 6 months children was influenced by receiving information about EBF, colostrum discharging, awareness of breast feeding is enough the child up to six month and antenatal care visit were significantly associated with EBF practice (P < 0.05).
Abstract: Breastfeeding has many health benefits for both mother and infant. Breast milk contains all the nutrients an infant need in the first 6 months of life. Exclusive breastfeeding is the most widely known and effective intervention for preventing early-childhood deaths. Optimum breastfeeding practices can prevent 1.4 million deaths worldwide among chil...
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The Physical Dose Difference of Three Types of Implantation on the CTV and Lungs in Interstitial Brachytherapy
Jing Zhang,
Bo Yang,
Haowen Pang,
Guangpeng Zhang,
Renjin Chen,
Lei Li
Issue:
Volume 8, Issue 2, March 2020
Pages:
50-55
Received:
11 April 2020
Accepted:
3 May 2020
Published:
28 May 2020
Abstract: Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the inclusion criteria: the CTV shape was approximately spherical and multiply needles arrangement was irregular. Thirteen lung cancer patients underwent interstitial brachytherapy were collected. Based on the thirteen CT data sets, the AIBP, VRBP and VSBP were respectively designed, then we collected the dose metrics involving: the minimum dosage received by 95% of the CTV (D95), D90, D80, D50 and D30; the percentage of lung volume receiving a dose of ≥ 5 Gy (V5), V20, V30 and the mean lung dose (MLD); D50 of heart; the maximum dose (Dmax) of spinal cord and the Dmax of ribs. The differences were tested by the two-sample paired (Wilcoxon) signed rank test, a P value less than 0.05 was considered statistically significant. Result: The differences of D95, D90, D80, D50 and D30 of CTV, D50 of heart, Dmax of spinal and Dmax of ribs were not statistical significant (P>0.05) and the V5, V20, V30 and MLD of lungs and ipsilateral lung were statistical significant (P<0.05) between AIBP and VRBP. The differences of D95, D90, D80 and D50 of CTV, D50 of heart, Dmax of spinal cord, Dmax of ribs, V5, V20, V30 and MLD of lungs and ipsilateral lung were not statistical significant (P>0.05) except for D30 of CTV (P<0.05) between AIBP and VRBP. Conclusion: In interstitial brachytherapy for lung tumor, the arrangement of implantation needles could influenced the dose distribution in target and lungs. If the CTV shape could be approximately considered to be a spherical and a regular arrangement of multiply needles was difficult to achieve; the lung dose of the AIBP might have no obvious advantage over the VSBP and the VSBP should be worth a try.
Abstract: Purpose: To study the difference of physical dose of target volume and lungs among actual irregular arrangement multi-needle interstitial brachytherapy plan (AIBP), virtual regular arrangement multi-needle interstitial brachytherapy plan (VRBP) and virtual single needle center point interstitial brachytherapy plan (VSBP). Methods: According to the ...
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Research on Expression of Integrin and EGF in Sterile Women During Endometrial Implantation Window
Wan Yingjun,
Ma Fengmei,
Zhao Changzhen
Issue:
Volume 8, Issue 2, March 2020
Pages:
56-62
Received:
14 April 2020
Published:
29 May 2020
Abstract: Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhibiting ovulation following PCOS ovulation induction treatment, 26 women exhibiting no ovulation following PCOS ovulation induction treatment, 38 women exhibiting oviduct obstruction, 32 women exhibiting hydrosalpinx. An immunohistochemical method was used to detect the expression of integrin and EGF in sterile women of the five groups of research objects during endometrial implantation window and a statistical analysis was conducted for all detection results. Results The expression level of the integrin in PCOS group is significantly lower than that in the control group and the difference is significant (P<0.05); the expression level of the integrin in PCOS anovulation group is significantly lower than that in PCOS ovulation group and there is statistical significance (P<0.05); the difference between the oviduct obstruction group and the control group is not significant (P>0.05); the expression level of the integrin in the hydrosalpinx group is lower than that in the oviduct obstruction group and the difference is significant (P<0.05). EGF is expressed in endometria of various groups of women and its expression is located in cytoplasm of epithelial cells of the endometrial gland. Conclusion Integrin and epidermal growth factor are expressed in endometria of various groups of women in the implantation phase indicating that they may be important regulatory factors for endometrial receptivity and embryonic implantation.
Abstract: Objective To study expression of integrin and epidermal growth factor in sterile patients during endometrial implantation window and discuss the relationship between the integrin and epidermal growth factor and endometrial receptivity. Methods: The research objects were divided into 5 groups with 30 women at the normal gestation age, 30 women exhib...
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